Erythrocyte membrane skeletal protein bands 4.1 a and b are sequence-related phosphoproteins.
نویسندگان
چکیده
منابع مشابه
Erythrocyte membrane deformability and stability: two distinct membrane properties that are independently regulated by skeletal protein associations
Skeletal proteins play an important role in determining erythrocyte membrane biophysical properties. To study whether membrane deformability and stability are regulated by the same or different skeletal protein interactions, we measured these two properties, by means of ektacytometry, in biochemically perturbed normal membranes and in membranes from individuals with known erythrocyte abnormalit...
متن کاملAlteration of the Erythrocyte Membrane Skeletal Ultrastructure
The membrane skeleton of normal erythrocytes is largely organized into a hexagonal lattice of junctional complexes (JC) crosslinked by spectrin tetramers, and occasional double tetramers and hexamers. To explore possible skeletal alterations in hereditary spherocytosis (HS), elliptocytosis (HE), and pyropoikilocytosis (HPP), we have studied the ultrastructure of the spread membrane skeletons fr...
متن کاملWhich protein bands are significant?
CASE DESCRIPTION The serum protein electrophoresis pattern (SPEP) for an 82-year-old female patient with known monoclonal gammopathy of undetermined significance demonstrated 2 aberrant protein bands, one in the 21 interzone (Fig. 1A, fat arrow) and one in the 12 interzone (Fig. 1A, thin arrow). The immunofixation electrophoresis (IFE) (Fig. 1B) revealed a large IgA paraprotein in the 12 interz...
متن کاملA variant of erythrocyte membrane skeletal protein band 4.1 associated with hereditary elliptocytosis.
A family comprising three patients (a mother and two children) with mild hereditary elliptocytosis was studied. Each patient had prominent elliptocytosis, reduced red cell deformability, and normal erythrocyte thermal sensitivity. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of the erythrocyte membranes in each patient showed decreased levels of band 4.1 (approximately h...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1982
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)34761-6